Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer.

ABSTRACT:

Background

Prognostication of patients with colorectal cancer (CRC) currently relies on tumor-node-metastasis (TNM) staging but clinical outcomes of patients of the same histoclinical stage are heterogeneous. It is therefore imperative to devise novel molecular tests to stratify CRC patients. Our previous work demonstrated that eukaryotic elongation factor-2 kinase (EEF2K) is a tumor suppressor in CRC. Herein, we investigated EEF2K expression in CRC and determined its relationship with clinicopathological parameters.

Methods

Quantitative RT-PCR and Westerns blots were used to examine EEF2K expression in primary tumor and the adjacent non-tumor tissues of CRC patients (n = 20). Kaplan-Meier curves and Cox regression analysis were used to assess the association between clinica

SUBMITTER: Ng TH 

PROVIDER: S-EPMC6607603 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature