Early-life sickness may predispose Siberian hamsters to behavioral changes following alterations of the gut microbiome in adulthood.

ABSTRACT: Although it is well-established that the immune system plays an important role in the development of physiology and behavior, the gut microbiome has recently become of interest in the study of developmental origins of behavior. Studies suggest that the effects of early-life immune activation may not occur until a secondary stressor is introduced, though the precise nature and timing of the stressor may be critical in the response. Further, recent work suggests that the microbiome and the immune system develop in parallel, and therefore any perturbations to one of these systems early in life will likely affect the other. Here, we sought to determine whether early-life activation of the immune system had long-term consequences on how the gut microbiome responds to antibiotic treatment in adu

SUBMITTER: Sylvia KE 

PROVIDER: S-EPMC6607895 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature