Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.

ABSTRACT:

Background

Prenatal cocaine exposure (PCE) is associated with arousal dysregulation, but interactions between exposure and age are rarely investigated directly with longitudinal study designs. Our previous study had examined task-elicited emotional arousal and noted persistently high amygdala activations in the development of adolescents with PCE. However, while externally imposed emotional arousal could be considered a "state" effect depending on specific task stimuli, it is still unclear whether similar developmental alterations extend to intrinsic functional connectivity (FC), reflecting more of a "trait" effect.

Methods

We used a longitudinal design and analyzed resting-state functional magnetic resonance imaging data acquired twice from 25 adolescents with PCE and 16 no

SUBMITTER: Li Z 

PROVIDER: S-EPMC6607904 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature