Variable Ventilation Is Equally Effective as Conventional Pressure Control Ventilation for Optimizing Lung Function in a Rabbit Model of ARDS.

ABSTRACT:

Background

Introducing mathematically derived variability (MVV) into the otherwise monotonous conventional mechanical ventilation has been suggested to improve lung recruitment and gas exchange. Although the application of a ventilation pattern based on variations in physiological breathing (PVV) is beneficial for healthy lungs, its value in the presence of acute respiratory distress syndrome (ARDS) has not been characterized. We therefore aimed at comparing conventional pressure-controlled ventilation with (PCS) or without regular sighs (PCV) to MVV and PVV at two levels of positive end-expiratory pressure (PEEP) in a model of severe ARDS.

Methods

Anesthetised rabbits (n = 54) were mechanically ventilated and severe ARDS (PaO₂/FiO₂ ≤ 150 mmHg) w

SUBMITTER: Fodor GH 

PROVIDER: S-EPMC6607923 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature