Disruption of Trim9 function abrogates macrophage motility in vivo.

ABSTRACT: The vertebrate immune response comprises multiple molecular and cellular components that interface to provide defense against pathogens. Because of the dynamic complexity of the immune system and its interdependent innate and adaptive functionality, an understanding of the whole-organism response to pathogen exposure remains unresolved. Zebrafish larvae provide a unique model for overcoming this obstacle, because larvae are protected against pathogens while lacking a functional adaptive immune system during the first few weeks of life. Zebrafish larvae were exposed to immune agonists for various lengths of time, and a microarray transcriptome analysis was executed. This strategy identified known immune response genes, as well as genes with unknown immune function, including the E3 ubiquiti

SUBMITTER: Tokarz DA 

PROVIDER: S-EPMC6608060 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature