Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice.

ABSTRACT: Oxytocin (OXT) has been shown to suppress appetite, induce weight loss, and improve glycemic control and lipid metabolism in several species, including humans, monkeys, and rodents. However, OXT's short half-life in circulation and lack of receptor selectivity limit its application and efficacy. In this study, we report an OXT peptide analog (OXT^Gly) that is potent and selective for the OXT receptor (OXTR). OXT, but not OXT^Gly, activated vasopressin receptors in vitro and acutely increased blood pressure in vivo when administered IP. OXT suppressed food intake in mice, whereas OXT^Gly had a moderate effect on food intake when administered IP or intracerebroventricularly. Both OXT (IP) and OXT^Gly (IP) improved glycemic control in gluc

SUBMITTER: Snider B 

PROVIDER: S-EPMC6608564 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature