Body Composition and Aspirin Dose for Colorectal Adenoma Prevention in a Randomized Clinical Trial.

ABSTRACT:

Background

Visceral adiposity is a risk factor for colorectal adenomas, and aspirin is an established chemopreventive agent. Evidence from clinical trials suggests the effectiveness of aspirin at preventing cardiovascular disease and cancer may require higher doses for higher body weight.

Methods

Body mass index, body surface area, fat-free mass, and fat mass were calculated from baseline height and weight in 1,121 participants of the Aspirin/Folate Polyp Prevention Study, a double-blind, placebo-controlled, 3 × 2 factorial randomized clinical trial of low-dose (81 mg/day) or high-dose (325 mg/day) aspirin and/or 1 mg/day folic acid to prevent metachronous colorectal adenomas. Participants were treated during a surveillance colonoscopy interval of approximately 3 years. Risk

SUBMITTER: Passarelli MN 

PROVIDER: S-EPMC6608598 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature