Radiation damage in small-molecule crystallography: fact not fiction.

ABSTRACT: Traditionally small-molecule crystallographers have not usually observed or recognized significant radiation damage to their samples during diffraction experiments. However, the increased flux densities provided by third-generation synchrotrons have resulted in increasing numbers of observations of this phenomenon. The diversity of types of small-molecule systems means it is not yet possible to propose a general mechanism for their radiation-induced sample decay, however characterization of the effects will permit attempts to understand and mitigate it. Here, systematic experiments are reported on the effects that sample temperature and beam attenuation have on radiation damage progression, allowing qualitative and quantitative assessment of their impact on crystals of a small-molecule tes

SUBMITTER: Christensen J 

PROVIDER: S-EPMC6608633 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature