Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides.

ABSTRACT: Sulfonamide drugs are well known antibacterial and antimicrobial molecules for pharmaceutical development. Building a library of suitable supramolecular synthons for the sulfonamide functional group and understanding their crystal structures with partner coformer molecules continues to be a challenge in crystal engineering. Although a few sulfonamide cocrystals with amides and N-oxides have been reported, the body of work on sulfonamide synthons is limited compared with those that have carb-oxy-lic acids and carboxamides. To address this structural gap, the present work is primarily focused on sulfonamide-lactam and sulfonamide-syn-amide synthons with drugs such as celecoxib, hydro-chloro-thia-zide and furosemide. Furthermore, the electrostatic potential of previously reporte

SUBMITTER: Bolla G 

PROVIDER: S-EPMC6608642 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature