Medical contrast media as possible tools for SAXS contrast variation.

ABSTRACT: Small-angle X-ray scattering (SAXS) is increasingly used to extract structural information from a multitude of soft-matter and biological systems in aqueous solution, including polymers, detergents, lipids, colloids, proteins and RNA/DNA. When SAXS data are recorded at multiple contrasts, i.e. at different electron densities of the solvent, the internal electron-density profile of solubilized molecular systems can be probed. However, contrast-variation SAXS has been limited by the range of electron densities available by conventional agents such as sugars, glycerol and salt, and by the fact that many soft-matter and biological systems are modified in their presence. Here we present a pioneering SAXS contrast-variation study on DDM (n-do-decyl-β-d-malto-pyran-oside) micelles b

SUBMITTER: Gabel F 

PROVIDER: S-EPMC6608644 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature