Multiscale mechanisms of tendon fatigue damage progression and severity are strain and cycle dependent.

ABSTRACT: Tendinopathies are common chronic injuries that occur when damage accumulation caused by sub-rupture fatigue loading outpaces repair. Studies have linked fatigue loading with various mechanical, structural, and biological changes associated with pathology. However, the multiscale progression of damage accumulation with respect to area, severity and the distinct contributions of strain level and number of cycles has not been fully elucidated. The objective of this study was to investigate multiscale mechanisms underlying fatigue damage accumulation and their effect on the cellular environment. Using an in situ model in rat tail tendon (RTT), fatigue loading was applied at various strains and cycle numbers to induce fatigue damage. Pre- and post- fatigue diagnostic mechanical testing, second

SUBMITTER: Ros SJ 

PROVIDER: S-EPMC6608713 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature