Low fasting glucose and future risks of major adverse outcomes in people without baseline diabetes or cardiovascular disease: a systematic review and meta-analysis.

ABSTRACT: OBJECTIVE:To investigate the link between low fasting blood glucose levels and all-cause mortality and cardiovascular outcomes among people without baseline diabetes or cardiovascular disease. DESIGN:Systematic review and meta-analysis. DATA SOURCES:PubMed and Embase (1966-February 2019). SELECTION CRITERIA:Prospective cohort studies were included for meta-analysis if they reported adjusted HRs with 95% CIs for associations between risk of all-cause mortality, stroke, major cardiovascular events, coronary heart disease and low fasting glucose levels (<4.6 mmol/L and/or 4.0 mmol/L, respectively) versus normal fasting glucose levels. DATA EXTRACTION AND STATISTICAL ANALYSIS:Two independent reviewers extracted data from eligible studies. Heterogeneity was assessed by p value of χ2 tests and I

SUBMITTER: Liao HW 

PROVIDER: S-EPMC6609056 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature