Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells.

ABSTRACT: Udenafil, which is a PDE₅ inhibitor, is used to treat erectile dysfunction. However, it is unclear whether udenafil induces hair growth via the stimulation of adipose-derived stem cells (ASCs). In this study, we investigated whether udenafil stimulates ASCs and whether increased growth factor secretion from ASCs to facilitate hair growth. We found that subcutaneous injection of udenafiltreated ASCs accelerated telogen-to-anagen transition in vivo. We also observed that udenafil induced proliferation, migration and tube formation of ASCs. It also increased the secretion of growth factors from ASCs, such as interleukin-4 (IL-4) and IL12B, and the phosphorylation of ERK1/2 and NFκB. Furthermore, concomitant upregulation of IL-4 and IL12B mRNA levels was attenuated by ERK inh

SUBMITTER: Choi N 

PROVIDER: S-EPMC6609107 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature