Drug resistance from preferred antiretroviral regimens for HIV infection in South Africa: A modeling study.

ABSTRACT:

Background

Tenofovir-containing regimens comprise the preferred first-line antiretroviral therapy (ART) in many countries including South Africa, where utilization of second-line regimens is limited. Considerable HIV drug resistance has occurred among persons failing tenofovir-containing first-line ART. We evaluated drug resistance at the population level using mathematical modeling.

Setting

Heterosexual HIV epidemic in KwaZulu-Natal, South Africa.

Methods

We constructed a stochastic individual-based model and simulated scenarios of ART implementation, either CD4-based (threshold < 500 cells/mL) or Fast-track (81% coverage by 2020), with consideration of major drug-associated mutations (M184V, K65R and non-nucleoside reverse transcriptase inhibitor (NNRTI)). Using bas

SUBMITTER: Abbas UL 

PROVIDER: S-EPMC6609148 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature