Local Administration of Caloric Restriction Mimetics to Promote the Immune Control of Lung Metastases.

ABSTRACT: Caloric restriction mimetics (CRMs), compounds that mimic the biochemical effects of nutrient deprivation, administered via systemic route promote antitumor effects through the induction of autophagy and the modulation of the immune microenvironment; however, collateral effects due to metabolic changes and the possible weight loss might potentially limit their administration at long term. Here, we investigated in mice local administration of CRMs via aerosol to reduce metastasis implantation in the lung, whose physiologic immunosuppressive status favors tumor growth. Hydroxycitrate, spermidine, and alpha-lipoic acid, CRMs that target different metabolic enzymes, administered by aerosol, strongly reduced implantation of intravenously injected B16 melanoma cells without overt signs of toxici

SUBMITTER: Le Noci V 

PROVIDER: S-EPMC6609366 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature