Detection of genomic regions underlying resistance to gastrointestinal parasites in Australian sheep.

ABSTRACT:

Background

This study aimed at identifying genomic regions that underlie genetic variation of worm egg count, as an indicator trait for parasite resistance in a large population of Australian sheep, which was genotyped with the high-density 600 K Ovine single nucleotide polymorphism array. This study included 7539 sheep from different locations across Australia that underwent a field challenge with mixed gastrointestinal parasite species. Faecal samples were collected and worm egg counts for three strongyle species, i.e. Teladorsagia circumcincta, Haemonchus contortus and Trichostrongylus colubriformis were determined. Data were analysed using genome-wide association studies (GWAS) and regional heritability mapping (RHM).

Results

Both RHM and GWAS detected a region on Ovis a

SUBMITTER: Al Kalaldeh M 

PROVIDER: S-EPMC6609385 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature