An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse.

ABSTRACT:

Background

Previously, we have demonstrated that genes involved in ovarian function are highly conserved throughout evolution. In this study, we aimed to document the conservation of genes involved in spermatogenesis from flies to vertebrates and their expression profiles in vertebrates.

Results

We retrieved 379 Drosophila melanogaster genes that are functionally involved in male reproduction according to their mutant phenotypes and listed their vertebrate orthologs. 83% of the fly genes have at least one vertebrate ortholog for a total of 625 mouse orthologs. This conservation percentage is almost twice as high as the 42% rate for the whole fly genome and is similar to that previously found for genes preferentially expressed in ovaries. Of the 625 mouse orthologs, we select

SUBMITTER: Fouchecourt S 

PROVIDER: S-EPMC6609395 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature