Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.

ABSTRACT: Circular RNAs (circRNAs) are known to be closely involved in tumorigenesis and cancer progression. Nevertheless, their function and underlying mechanisms in renal cell carcinoma (RCC) remain largely unknown. The aim of the present study was to explore their expression, functions, and molecular mechanisms in RCC. We downloaded the circRNA expression profiles from Gene Expression Omnibus (GEO) database, and RNA expression profiles from The Cancer Genome Atlas (TCGA) database. A ceRNA network was constructed based on circRNA-miRNA pairs and miRNA-mRNA pairs. Interactions between proteins were analyzed using the STRING database, and hub genes were identified using the cytoHubba app. We also constructed a circRNA-miRNA-hub gene regulatory module. Functional and pathway enrichment analyses were

SUBMITTER: Jiang WD 

PROVIDER: S-EPMC6609600 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature