Diagnostic performance of regional cerebral blood flow images derived from dynamic PIB scans in Alzheimer's disease.

ABSTRACT:

Background

In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer's disease (AD) through 2-[¹⁸F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scans. However, visual assessment of the characteristic AD hypometabolic pattern relies on the expertise of the reader. Therefore, user-independent pipelines are preferred to evaluate the images and to classify the subjects. Moreover, glucose consumption is highly correlated with cerebral perfusion. Regional cerebral blood flow (rCBF) images can be derived from dynamic ¹¹C-labelled Pittsburgh Compound B PET scans, which are also used for the assessment of the deposition of amyloid-β plaques on the brain, a fundamental characteristic of AD. Th

SUBMITTER: Peretti DE 

PROVIDER: S-EPMC6609664 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature