Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.

ABSTRACT: NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. The core mechanism for this form of plasticity is thought to be entirely neuronal. However, we now demonstrate that astrocytic activity drives LTD at CA3-CA1 synapses. We have found that LTD induction enhances astrocyte-to-neuron communication mediated by glutamate, and that Ca²⁺ signaling and SNARE-dependent vesicular release from the astrocyte are required for LTD expression. In addition, using optogenetic techniques, we show that low-frequency astrocytic activation, in the absence of presynaptic activity, is sufficient to induce postsynaptic AMPA receptor removal and LTD expression. Using cell-type-specific ge

SUBMITTER: Navarrete M 

PROVIDER: S-EPMC6609681 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature