High-throughput analysis of the human thymic Vδ1⁺ T cell receptor repertoire.

ABSTRACT: γδ T cells are a relatively rare subset of lymphocytes in the human peripheral blood, but they play important roles at the interface between the innate and the adaptive immune systems. The γδ T cell lineage is characterized by a signature γδ T cell receptor (γδTCR) that displays extensive sequence variability originated by DNA rearrangement of the corresponding V(D)J loci. Human γδ T cells comprise Vγ9Vδ2 T cells, the major subset in the peripheral blood; and Vδ1⁺ T cells, the predominant subpopulation in the post-natal thymus and in peripheral tissues. While less studied, Vδ1⁺ T cells recently gathered significant attention due to their anti-cancer and anti-viral activities. In this study we applied next-generation sequencing (NGS) to analyse the γδTCR repertoire of

SUBMITTER: Di Lorenzo B 

PROVIDER: S-EPMC6609709 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature