Long-term prognostic significance of interleukin-17-producing T cells in patients with non-small cell lung cancer.

ABSTRACT: The presence of interleukin (IL)-17-producing T cells has recently been reported in non-small cell lung cancer (NSCLC) patients. However, the long-term prognostic significance of these populations in NSCLC patients remains unknown. In the present study, we collected peripheral blood from 82 NSCLC patients and 22 normal healthy donors (NC). Percentages of IL-17-producing CD4⁺ T (Th17), CD8⁺ T (Tc17) and γδT cells (γδT17) were measured to determine their association with clinical outcomes and overall survival (OS) in NSCLC. All NSCLC patients were followed up until July 2018. Median follow-up time was 13.5 months (range 1-87 months). The 3- and 5-year survival rate was 27% and 19.6%, respectively. We found that Th17 cells and γδT17 cells were significantly increased, wh

SUBMITTER: Song L 

PROVIDER: S-EPMC6609818 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature