Axl-Targeted Delivery of the Oncosuppressor miR-137 in Non-small-Cell Lung Cancer.

ABSTRACT: Non-small-cell lung cancer (NSCLC) accounts for 85%-90% of all cases of lung cancer that is the most deadly type of cancer. Despite advances in chemotherapy and radiotherapy, severe side effects and frequent drug resistance limit the success of the treatments, and the identification of new therapeutic options still represents a crucial challenge. Here, we provide the evidence for the therapeutic potential of an aptamer-microRNA (miR) complex (AmiC) composed by an aptamer (GL21.T), able to bind and antagonize the oncogenic receptor Axl, and the miR-137, downregulated in lung cancer and involved in cell survival and proliferation. We found that, when applied to Axl-expressing NSCLC cancer cells, the complex is effectively internalized, increasing miR cellular levels and downregulating miR ta

SUBMITTER: Nuzzo S 

PROVIDER: S-EPMC6609832 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature