Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma.

ABSTRACT: Vasohibin-2 (VASH2) is expressed in various cancers and promotes their progression. We recently reported that pancreatic cancer patients with higher VASH2 expression show poorer prognosis. Herein, we sought to characterize the role of VASH2 in pancreatic cancer. We used LSL-Kras^G12D ; LSL-Trp53^R172H ; Pdx-1-Cre (KPC) mice, a mouse model of pancreatic ductal adenocarcinoma (PDAC), and cells isolated from them (KPC cells). Knockdown of Vash2 from PDAC cells did not affect their proliferation, but decreased their migration. When Vash2-knockdown PDAC cells were orthotopically inoculated, liver metastasis and peritoneal dissemination were reduced, and the survival period was significantly prolonged. When KPC mice were crossed with Vash2-deficient mice, metastasis was signi

SUBMITTER: Iida-Norita R 

PROVIDER: S-EPMC6609860 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature