Biological analysis of flexor tendon repair-failure stump tissue: A potential recycling of tissue for tendon regeneration.

ABSTRACT:

Objectives

Re-rupture is common after primary flexor tendon repair. Characterization of the biological changes in the ruptured tendon stumps would be helpful, not only to understand the biological responses to the failed tendon repair, but also to investigate if the tendon stumps could be used as a recycling biomaterial for tendon regeneration in the secondary grafting surgery.

Methods

A canine flexor tendon repair and failure model was used. Following six weeks of repair failure, the tendon stumps were analyzed and characterized as isolated tendon-derived stem cells (TDSCs).

Results

Failed-repair stump tissue showed cellular accumulation of crumpled and disoriented collagen fibres. Compared with normal tendon, stump tissue had significantly higher gene expression of

SUBMITTER: Lu CC 

PROVIDER: S-EPMC6609868 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature