In patients with heart failure the burden of central sleep apnea increases in the late sleep hours.

ABSTRACT:

Study objectives

Periodic breathing with central sleep apnea (CSA) is common in patients with left ventricular systolic dysfunction. Based on the pathophysiological mechanisms underlying CSA, we hypothesized that the frequency of CSA episodes would increase in the late hours of non-rapid eye movement (NREM) of sleep.

Methods

Forty-one patients with left ventricular ejection fraction <40% underwent full-night-attended polysomnography scored by a central core lab. Because central apneas occur primarily in NREM sleep, total NREM sleep time for each patient was divided into 8 equal duration segments. Segment event counts were normalized to an events/hour index based on sleep segment duration.

Results

Central apnea index (CAI) varied among sleep segments (p = 0.001). As ex

SUBMITTER: Javaheri S 

PROVIDER: S-EPMC6609878 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature