Regression to Normal Glucose Regulation in American Indians and Alaska Natives of a Diabetes Prevention Program.

ABSTRACT:

Objective

This study evaluated whether regression from impaired glucose regulation (IGR) to normal glucose regulation (NGR) after 1 year of a lifestyle intervention reduces diabetes risk in American Indians and Alaska Natives (AI/ANs). In addition, we sought to identify predictors for regression to NGR and understand possible mechanisms for the association between NGR and future diabetes risk.

Research design and methods

Data from participants enrolled from 2006 to 2009 in the Special Diabetes Program for Indians Diabetes Prevention Program with IGR at baseline and an oral glucose tolerance test at year 1 were analyzed (N = 1,443). Cox regression models were used to estimate the subsequent diabetes risk (year 1 to year 3) by year 1 glucose status. Mediation analysis w

SUBMITTER: Pratte KA 

PROVIDER: S-EPMC6609959 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature