Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.

ABSTRACT:

Context

To our knowledge, circadian rhythms have not been examined in girls with polycystic ovarian syndrome (PCOS), despite the typical delayed circadian timing of adolescence, which is an emerging link between circadian health and insulin sensitivity (SI), and decreased SI in PCOS.

Objective

To examine differences in the circadian melatonin rhythm between obese adolescent girls with PCOS and control subjects, and evaluate relationships between circadian variables and SI.

Design

Cross-sectional study.

Participants

Obese adolescent girls with PCOS (n = 59) or without PCOS (n = 33).

Outcome measures

Estimated sleep duration and timing from home actigraphy monitoring, in-laboratory hourly sampled dim-light, salivary-melatonin and fasting hormone analysis.<

SUBMITTER: Simon SL 

PROVIDER: S-EPMC6610211 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature