Towards microvascular pressure estimation using ultrasound and photoacoustic imaging.

ABSTRACT: Microvascular pressure drives perfusion in tissues but is difficult to measure. A method is proposed here to estimate relative pressures in microvessels using photoacoustic and ultrasound tracking of small vessels during calibrated tissue compression. A photoacoustic-ultrasound dual imaging transducer is used to directly compress on tissue in vivo. Photoacoustic signals from blood vessels diminish as an external load is applied and eventually reaches a minimum or vanishes when external pressure is sufficiently greater than the internal pressure. Two methods were proposed to estimate relative pressures. In the first approach, vessels were tracked during compression and when the vessel photoacoustic signals vanished below a set threshold, the internal pressures were assigned as the ex

SUBMITTER: Choi M 

PROVIDER: S-EPMC6610233 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature