Synergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO₂ nanosheets.

ABSTRACT: The biodegradability and clearance of metal-based nanomaterials have been questioned worldwide, which have greatly limited their clinical translation. Herein, ultrathin manganese dioxide (MnO₂) nanosheets with broad near-infrared (NIR) absorption and pH-dependent degradation properties were prepared. After being modified with polyethylene glycol-cyclic arginine-glycineaspartic acid tripeptide (PEG-cRGD), the MnO₂ nanosheets were then used as photothermal agent and nanocarrier to encapsulate chlorin e6 (Ce6) for targeted photothermal (PTT) and photodynamic (PDT) of cancer. As expected, the MnO₂-PEG-cRGD nanosheets show high Ce6 loading capacity (351 mg/g), superb photothermal conversion performance (37.2%) and excellent colloidal stability. These nanosheets

SUBMITTER: Zeng D 

PROVIDER: S-EPMC6610525 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature