The effects of resveratrol feeding and exercise training on the skeletal muscle function and transcriptome of aged rats.

ABSTRACT: This study investigated the effects of resveratrol feeding and exercise training on the skeletal muscle function and transcriptome of aged rats. Male SD rats (25 months old) were divided into the control group (Old), the daily exercise training group (Trained), and the resveratrol feeding group (Resveratrol). After 6 weeks of intervention, the body mass, grip strength, and gastrocnemius muscle mass were determined, and the muscle samples were analyzed by transcriptome sequencing. The differentially expressed genes were analyzed followed by GO enrichment analysis and KEGG analysis. The Old group showed positive increases in body mass, while both the Trained and Resveratrol groups showed negative growth. No significant differences in the gastrocnemius muscle index and absolute grip strength

SUBMITTER: Zhou J 

PROVIDER: S-EPMC6610545 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature