Dataset Information

The Relationships Between Time in Range, Hyperglycemia Metrics, and HbA1c.

ABSTRACT:

Background

As the use of continuous glucose monitoring (CGM) increases, there is a need to better understand key metrics of time in range 70-180 mg/dL (TIR^70-180) and hyperglycemia and how they relate to hemoglobin A1c (A1C).

Methods

Analyses were conducted utilizing datasets from four randomized trials encompassing 545 adults with type 1 diabetes (T1D) who had central-laboratory measurements of A1C. CGM metrics were calculated and compared with each other and A1C cross-sectionally and longitudinally.

Results

Correlations among CGM metrics (TIR^70-180, time >180 mg/dL, time >250 mg/dL, mean glucose, area under the curve above 180 mg/dL, high blood glucose index, and time in range 70-140 mg/dL) were typically 0.90 or greater. Correlations of each metric with A1C were lower (absolute values 0.66-0.71 at baseline and 0.73-0.78 at month 6). For a given TIR^70-180 percentage, there was a wide range of possible A1C levels that could be associated with that TIR^70-180 level. On average, a TIR^70-180 of 70% and 50% corresponded with an A1C of approximately 7% and 8%, respectively. There also was considerable spread of change in A1C for a given change in TIR^70-180, and vice versa. An increase in TIR^70-180 of 10% (2.4 hours per day) corresponded to a decrease in A1C of 0.6%, on average.

Conclusions

In T1D, CGM measures reflecting hyperglycemia (including TIR and mean glucose) are highly correlated with each other but only moderately correlated with A1C. For a given TIR or change in TIR there is a wide range of possible corresponding A1C values.

SUBMITTER: Beck RW

PROVIDER: S-EPMC6610606 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

The Relationships Between Time in Range, Hyperglycemia Metrics, and HbA1c.

Beck Roy W RW Bergenstal Richard M RM Cheng Peiyao P Kollman Craig C Carlson Anders L AL Johnson Mary L ML Rodbard David D

Journal of diabetes science and technology 20190113 4

<h4>Background</h4>As the use of continuous glucose monitoring (CGM) increases, there is a need to better understand key metrics of time in range 70-180 mg/dL (TIR<sup>70-180</sup>) and hyperglycemia and how they relate to hemoglobin A1c (A1C).<h4>Methods</h4>Analyses were conducted utilizing datasets from four randomized trials encompassing 545 adults with type 1 diabetes (T1D) who had central-laboratory measurements of A1C. CGM metrics were calculated and compared with each other and A1C cross ...[more]

PMID: 30636519

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Dataset Information

The Relationships Between Time in Range, Hyperglycemia Metrics, and HbA1c.

Background

Methods

Results

Conclusions

Publications

The Relationships Between Time in Range, Hyperglycemia Metrics, and HbA1c.

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