Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation.

ABSTRACT: Elucidation of the sequence of events underlying the dynamic interaction between transcription factors and chromatin states is essential. Maternal transcription factors function at the top of the regulatory hierarchy to specify the primary germ layers at the onset of zygotic genome activation (ZGA). We focus on the formation of endoderm progenitor cells and examine the interactions between maternal transcription factors and chromatin state changes underlying the cell specification process. Endoderm-specific factors Otx1 and Vegt together with Foxh1 orchestrate endoderm formation by coordinated binding to select regulatory regions. These interactions occur before the deposition of enhancer histone marks around the regulatory regions, and these TFs recruit RNA polymerase II, regulate enhance

SUBMITTER: Paraiso KD 

PROVIDER: S-EPMC6610736 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature