Allelic variants of breast cancer susceptibility genes PALB2 and RECQL in the Latvian population.

ABSTRACT:

Background

Large-scale case control studies revealed a number of moderate risk - low frequency breast cancer alleles of the PALB2 and RECQL genes. Some of these were reported as founder variants of Central and Eastern Europe. Based on highly similar founder variant spectra of the BRCA1 in Poland and Latvia, we decided to test the frequency of other common variants of moderate breast cancer risk - c.509_510delGA (rs515726124) and c.172_175delTTGT (rs180177143) of the PALB2 gene and c.1667_1667+3delAGTA variant of the RECQL gene in a breast cancer case-control series from Latvia to better understand the role of genes in susceptibility to breast cancer and their clinical significance.

Methods

The case-control study was performed based on an un

SUBMITTER: Hilz P 

PROVIDER: S-EPMC6610821 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature