Strong association between metabolically-abnormal obesity and gallstone disease in adults under 50 years.

ABSTRACT:

Background

Age, obesity, and metabolic syndrome are known risk factors for gallstones; however, the combined impact of these different risk factors on gallstone formation has not yet been examined.

Methods

This retrospective, cross-sectional study involved 3190 participants, including 207 participants (6.5%) with gallstones and 986 (30.9%) with metabolic syndrome. Participants were divided into four phenotypes according to metabolic syndrome and obesity status: 1378 participants were metabolically healthy and non-obese (MHNO); 826 were metabolically healthy but obese (MHO); 185 were metabolically abnormal but not obese (MANO); and 801 participants were metabolically abnormal and obese (MAO).

Results

The MAO and MANO phenotypes had more gallstones than the MHO and MHNO

SUBMITTER: Su PY 

PROVIDER: S-EPMC6610843 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature