Immunoproteomics to identify Staphylococcus aureus antigens expressed in bovine milk during mastitis.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen affecting both human and animal species. An effective vaccine to prevent S. aureus bovine disease and transmission would have positive effects on animal well-being, food production, and human health. The objective of this study was to identify multiple antigens that are immunoreactive during udder colonization and disease for exploration as vaccine antigens to prevent bovine mastitis. Staphylococcus aureus produces several cell wall-anchored and surface-associated virulence factors that play key roles in the pathogenesis of mastitis. Many of these proteins are conserved between different strains of S. aureus and represent promising vaccine candidates. We used an immunoproteomics approach to identify antigenic proteins from the surface of S

SUBMITTER: Misra N 

PROVIDER: S-EPMC6610883 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature