Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure.

ABSTRACT:

Background

Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (DCM), due to an impaired catabolism of BCAA, and if stimulating cardiac BCAA oxidation can improve cardiac function in mice with heart failure.

Method

For human cohorts of DCM and control, both male and female patients of ages between 22 and 66 years were recruited with informed consent from University of Alberta hospital. Left ventricular biopsies were obtained at the time of transplantation. Control biopsies were obtained from non-transplanted donor hearts without heart disease history. To determine if stimulating BCAA catabolism could

SUBMITTER: Uddin GM 

PROVIDER: S-EPMC6610921 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature