Using genetic variation in Aedes aegypti to identify candidate anti-dengue virus genes.

ABSTRACT:

Background

Transcriptomic profiling has generated extensive lists of genes that respond to viral infection in mosquitoes. These gene lists contain two types of genes; (1) those that are responsible for the insect's natural antiviral defense mechanisms, including some known innate immunity genes, and (2) genes whose change in expression may occur simply as a result of infection. As genetic modification tools for mosquitoes continue to improve, the opportunities to make refractory insects via allelic replacement or delivery of small RNAs that alter gene expression are expanding. Therefore, the ability to identify which genes in transcriptional profiles may have immune function has increasing value. Arboviruses encounter a range of mosquito tissues and physiologies as they traverse fr

SUBMITTER: Terradas G 

PROVIDER: S-EPMC6611004 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature