Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms.

ABSTRACT:

Background

Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice in China for centuries. We have found a correlation between the indications of WMP and the typical symptoms of pancreatic neoplasms. However, the pharmacological mechanisms of WMP still remain unknown.

Methods

In the present work, we used a network pharmacological method to predict its underlying complex mechanism of treating pancreatic neoplasms. Firstly, we obtained relative compounds of WMP based on TCMSP database, TCM database@Taiwan and TCMID database and collected potential targets of these compounds by target fishing. Then we built the pancreatic neoplasms target database by CTD, TTD, PharmGKB. Based on the matching results between WMP pot

SUBMITTER: Wan Y 

PROVIDER: S-EPMC6611005 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature