Development and validation of three machine-learning models for predicting multiple organ failure in moderately severe and severe acute pancreatitis.

ABSTRACT:

Background

Multiple organ failure (MOF) is a serious complication of moderately severe (MASP) and severe acute pancreatitis (SAP). This study aimed to develop and assess three machine-learning models to predict MOF.

Methods

Patients with MSAP and SAP who were admitted from July 2014 to June 2017 were included. Firstly, parameters with significant differences between patients with MOF and without MOF were screened out by univariate analysis. Then, support vector machine (SVM), logistic regression analysis (LRA) and artificial neural networks (ANN) models were constructed based on these factors, and five-fold cross-validation was used to train each model.

Results

A total of 263 patients were enrolled. Univariate analysis screened out sixteen parameters referring to bloo

SUBMITTER: Qiu Q 

PROVIDER: S-EPMC6611034 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature