Large-scale analysis of B-cell epitopes of envelope: Implications for Zika vaccine and immunotherapeutic development.

ABSTRACT: Background: Cases of the re-emergence of Zika virus in 2015 were associated with severe neurologic complications, including Gillien-Barre syndrome in adults and congenital Zika syndrome in newborns. The major structural determinant of immunity to the Zika virus is the E protein. Although B-cell epitopes of Zika E protein were recently identified, data regarding epitope variations among Zika strains in pre-epidemic and epidemic periods are lacking. Methods: Here, we conducted systematic bioinformatics analyses of Zika strains isolated between 1968 and 2017. Multiple sequence alignment of E protein as well as B-cell epitopes annotations were performed. In addition, homology-based approach was utilized to construct three-dimensional structures of monomeric E glycoproteins to ann

SUBMITTER: Almansour I 

PROVIDER: S-EPMC6611143 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature