Dose and Diet - Sources of Arsenic Intake in Mouse in Utero Exposure Scenarios.

ABSTRACT: In humans, early life exposure to inorganic arsenic is associated with adverse health effects. Inorganic arsenic in utero or in early postnatal life also produces adverse health effects in offspring of pregnant mice that consumed drinking water containing low part per billion levels of inorganic arsenic. Because aggregate exposure of pregnant mice to inorganic arsenic from both drinking water and food has not been fully evaluated in experimental studies, quantifying arsenic exposure of the developing mouse is problematic. Here, we determined levels of total arsenic and arsenic species in natural ingredient rodent diets that are composed of many plant and animal-derived foodstuffs and in a purified ingredient rodent diet that is composed of a more restricted mixture of foodstuffs. In natura

SUBMITTER: Murko M 

PROVIDER: S-EPMC6611170 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature