Synaptic Mechanisms for Bandwidth Tuning in Awake Mouse Primary Auditory Cortex.

ABSTRACT: Spatial size tuning in the visual cortex has been considered as an important neuronal functional property for sensory perception. However, an analogous mechanism in the auditory system has remained controversial. In the present study, cell-attached recordings in the primary auditory cortex (A1) of awake mice revealed that excitatory neurons can be categorized into three types according to their bandwidth tuning profiles in response to band-passed noise (BPN) stimuli: nonmonotonic (NM), flat, and monotonic, with the latter two considered as non-tuned for bandwidth. The prevalence of bandwidth-tuned (i.e., NM) neurons increases significantly from layer 4 to layer 2/3. With sequential cell-attached and whole-cell voltage-clamp recordings from the same neurons, we found that the bandwidth pref

SUBMITTER: Li H 

PROVIDER: S-EPMC6611464 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature