Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids.

ABSTRACT: Sleep seems essential to proper functioning of the prefrontal cortex (PFC). The role of different neurotransmitters has been studied, mainly the catecholamines and serotonin. Less attention has been paid to the amino acid transmitters and histamine. Here, we focus on the activity of these molecules in the PFC during sleep and sleep deprivation (SD). We determined extracellular concentrations of histamine and 8 amino acids in the medial PFC before, during and after SD. Additionally, we systematically reviewed the literature on studies reporting microdialysis measurements relating to sleep throughout the brain. In our experiment, median concentrations of glutamate were higher during SD than during baseline (p = 0.013) and higher during the dark-active than during the resting phase (p = 0.003

SUBMITTER: Leenaars CHC 

PROVIDER: S-EPMC6611484 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature