Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis.

ABSTRACT:

Purpose

To find safer and more effective drugs than mitomycin C to prevent conjunctival fibrosis in a rabbit model.

Methods

Twenty-four rabbits were involved and randomly divided into four groups. Limbus-based peritomy was performed at the superior cornea, and normal saline (NS group), mitomycin C (MMC group), SR (SR group), or TC (TC group)-coated silicone plate was inserted at the sub-Tenon's space in each group. Conjunctival congestion was evaluated at 1 and 4 weeks postoperatively. At 4 weeks, the numbers of inflammatory cells, fibroblasts, myofibroblasts, blood vessels, and goblet cells were counted in the conjunctiva and Tenon's capsule around the silicone plate.

Results

At 4 weeks, conjunctival congestion was significantly less than that observed at 1 week in t

SUBMITTER: Yoon SY 

PROVIDER: S-EPMC6611608 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature