Antibiotic resistance and molecular characterization of bacteremia Escherichia coli isolates from newborns in the United States.

ABSTRACT:

Background

Escherichia coli is a major cause of neonatal sepsis. Contemporary antibiotic resistance data and molecular characterization of neonatal E. coli bacteremia isolates in the US are limited.

Methods

E. coli blood isolates, antibiotic susceptibility data, and clinical characteristics were obtained from prospectively identified newborns from 2006 to 2016. The E. coli isolates were classified using an updated phylogrouping method and multi-locus sequence typing. The presence of several virulence traits was also determined.

Results

Forty-three newborns with E. coli bacteremia were identified. Mean gestational age was 32.3 (SD±5.4) weeks. Median age was 7 days (interquartile range 0-10). Mortality (28%) occurred exclusively in preterm newborns. Resistance to ampici

SUBMITTER: Cole BK 

PROVIDER: S-EPMC6611611 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature