Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry.

ABSTRACT: Despite the attractiveness of breath analysis as a non-invasive means to retrieve relevant metabolic information, its introduction into routine clinical practice remains a challenge. Among all the different analytical techniques available to interrogate exhaled breath, secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) offers a number of advantages (e.g., real-time, yet wide, metabolome coverage) that makes it ideal for untargeted and targeted studies. However, so far, SESI-HRMS has relied mostly on lab-built prototypes, making it difficult to standardize breath sampling and subsequent analysis, hence preventing further developments such as multi-center clinical studies. To address this issue, we present here a number of new developments. In particular, we have

SUBMITTER: Singh KD 

PROVIDER: S-EPMC6611759 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature