Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine.

ABSTRACT: Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity. Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge model. Nasal microbiota profiles at baseline are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration. Corynebacterium/Dolosigranulum-dominated profiles are associated with low-density colonization. Lowest rates of natural viral co-infection at base

SUBMITTER: de Steenhuijsen Piters WAA 

PROVIDER: S-EPMC6611866 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature