JC Virus and APOL1 Risk Alleles in Black South Africans With Hypertension-Attributed CKD.

ABSTRACT:

Introduction

The polyomaviruses, John Cunningham (JC) and BK, infect humans, with primary infection occurring in childhood. First-degree relatives of African American individuals with nondiabetic chronic kidney disease (CKD) who had 2 apolipoprotein L1 (APOL1) risk variants had a lower prevalence of kidney disease in the presence of JC viruria. This study determined the prevalence of polyomavirus infections and their effects, in the presence APOL1 risk alleles, on CKD.

Methods

Sixty-four black South African individuals with hypertension-attributed CKD with an estimated glomerular filtration rate (eGFR) ≤60 ml/min per 1.73 m², 44 first-degree relatives, and 56 unrelated controls were included. Viral DNA was extracted from urine and genomic DNA from bl

SUBMITTER: Nqebelele NU 

PROVIDER: S-EPMC6611950 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature