Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo.

ABSTRACT:

Background

Vitiligo is an acquired autoimmune skin disorder. The often-visible lesions of vitiligo have a major impact on patients' quality of life and the results of the treatment regimens on offer are unsatisfactory, so there is a need for new therapeutic regimens. Recent advances in vitiligo pathogenesis have led to recognition of the importance of the JAK-STAT pathway as an attractive therapeutic option.

Purpose

To evaluate role of JAK1 and STAT3 in vitiligo.

Methods

This prospective case-control study was carried out on 35 patients presenting with vitiligo and 20 apparently healthy age- and sex-matched volunteers. Skin biopsies from controls and cases were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.

Results

Epidermal and

SUBMITTER: Samaka RM 

PROVIDER: S-EPMC6612046 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature